Myostatin Stimulates, Not Inihibits, C2C12 Myoblast Proliferation
نویسندگان
چکیده
منابع مشابه
Enhancement of C2C12 myoblast proliferation and differentiation by GASP-2, a myostatin inhibitor
BACKGROUND GASP-2 is a secreted multi-domain glycoprotein known as a specific inhibitor of myostatin and GDF-11. Here we investigate the role of GASP-2 on myogenesis and the effect of its glycosylation on its activity. METHODS GASP-2 overexpression or knockdown by shRNAs were carried out on C2C12 myoblasts cells. In silico analysis of GASP-2 protein was performed to identify its glycosylation...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2014
ISSN: 0013-7227,1945-7170
DOI: 10.1210/en.2013-2107